MMP® has been successfully used to repigment idiopathic guttate hypomelanosis .In April 2014, a 49-year-old man, Fitzpatrick skin phototype III, complained of achromic scars in his left deltoid region (Fig. 1a) after 18 laser tattoo removal sessions (with Q-Switched 755 and 1064). We injected an endovenous solution (50 mg/mL) of 5-fluorouracil (5-FU) in the achromic scars using the MMP® drug delivery technique.
After five MMP® sessions (with 1-month intervals), the scars were completely repigmented (Fig. 1 and 2). Appearance remained unchanged 3 years after the last session. Achromic laser tattoo scars. a Baseline achromic scars in left deltoid region after 18 laser tattoo removal treatment sessions. Note: The patient was suntanned. b Same area after five MMP® sessions with 5-FU.
a, b Images using the Antera 3D® colorimetry system at baseline (a), and after three MMP® sessions with 5-FU (b). The areas outlined in black correspond to where we assessed melanin levels using the Antera 3D® software (c). c Average melanin level in a (red bar) and b (blue bar) using the Antera 3D® software.This case shows the successful use of a novel, simple, and inexpensive method to repigment achromic laser tattoo removal scars.Patients who seek laser treatment to eliminate their tattoos expect a near perfect result.
However, most are unaware that laser treatments can have permanent side effects, even when the dermatologist uses the best available technique and equipment [1-4]. Despite this information, most patients react negatively and demand a solution when achromic scars appear during or soon after laser tattoo removal treatment. Delivery of 5-FU into achromic scars using the MMP® technique is an easily available, effective, and inexpensive solution for these cases – are tattoo removal effective.
The esthetic results of the procedure can help to reduce patients’ frustrations and complaints about one of the side effects of laser tattoo removal treatment. We have been successfully using this drug delivery technique in our daily practice to repigment achromic scars over the last 3 years.We hypothesize that the anti-fibrotic properties of 5-FU reduce fibrosis in the papillary dermis and stimulate melanogenesis.
This IRB is registered in the United States Department of Health and Human Services – The Office for Human Research Protections (OHRP); IRB number 00001889, valid until 10/31/2018 and FWA 000023673, valid until 11/27/2020.Conflicts of interest of the main author were discussed in this journal . Since tattooing is an ancient technique under public domain done mainly by tattoo artists, we have chosen to copyright the acronym “MMP” in Brazil and the USA and grant free use exclusively to dermatologists who are members of the Brazilian Society of Dermatology (Sociedade Brasileira de Dermatologia – SBD) and equivalent entities around the world.
We inform that the clinical results described and documented herein can be achieved using any available tattoo machine (what tattoo removal cream works). The machine, its cartridges, and the medicines used in this study were supplied by Traderm (São José dos Campos, Brazil). The first author is part of a team that trains Brazilian dermatologists in the use of this technique.The first author is the owner of Traderm, a profit-oriented company that sells tattoo machines and cartridges for tattoo machines to be used by medical doctors.
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Tattooing is an ancient technique under public domain done mainly by tattoo artists. We have copyrights to the acronym MMP® in Brazil, United States, and Europe and grant free use exclusively to dermatologists who are members of the Brazilian Society of Dermatology and equivalent entities around the world. Dr Arbache’s commercial involvement in this investigation was required in order to obtain approval of the equipment for medical use under Brazilian health legislation (as enforced by Agência Nacional de Vigilância Sanitária) and to have this study submitted to the IRB committee.
Dr Arbache is part of a team that trains Brazilian dermatologists in the use of this technique.The tattooing machine, cartridges, and drug used in this study were supplied by Traderm (São José dos Campos, Brazil).Samir Arbache, main author. Dirlene Roth, participated in generating and gathering the data for the study.
Sergio Henrique Hirata, writing the draft and the paper. Eklund Y, Rubin AT. Laser tattoo removal, precautions, and unwanted effects. Curr Probl Dermatol. 2015;48:88–96. Karsai S. Removal of Tattoos by Q-Switched Nanosecond Lasers. Curr Probl Dermatol. 2017;52:105–12. Kirby W, Chen CL, Desai A, Desai T. Causes and recommendations for unanticipated ink retention following tattoo removal treatment.
2013 Jul;6(7):27–31. Wenzel S, Landthaler M, Baumler W. Recurring mistakes in tattoo removal. A case series. Dermatology. 2009;218(2):164–7. Fulton JE Jr., Rahimi AD, Mansoor S, Helton P, Shitabata P. The treatment of hypopigmentation after skin resurfacing. Dermatol Surg. 2004 Jan;30(1):95–101. Arbache S, Godoy C. Microinfusion of drugs into the skin with tattoo equipment.
2013;5:70–4. Arbache S, Roth D, Steiner D, Breunig J, Michalany NS, Arbache ST, et al. Activation of melanocytes in idiopathic guttate hypomelanosis after 5-fluorouracil infusion using a tattoo machine: preliminary analysis of a randomized, split-body, single blinded, placebo controlled clinical trial. J Am Acad Dermatol. 2018 Jan;78(1):212–5. Arbache S. REPLY to MS#JAAD-D-18-00380.
2018 Jun;79(4) – can tattoo removal cause skin cancer. Arbache S, Mattos EDC, Diniz MF, Paiva PYA, Roth D, Arbache ST, Oliveira ELT, Michalany NS, Hirata SH. How much medication is delivered in a novel drug delivery technique that uses a tattoo machine? Int J Dermatol. 2019 Jun;58(6):750–755. Rabey NG, Goldie SJ, Price RD. 5-Fluorouracil for keloid scars.
2017;9:CD012792. Gauthier Y, Anbar T, Lepreux S, Cario-André M, Benzekri L. Possible mechanisms by which topical 5-fluorouracil and dermabrasion could induce pigment spread in vitiligo skin: an experimental study. ISRN Dermatol. 2013 Apr 9;2013:852497. Jones CD, Guiot L, Samy M, Gorman M, Tehrani H: The use of chemotherapeutics for the treatment of keloid scars.
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2015 May 21;7(2):5880. Samir Arbache, MDRua Coronel Madeira 45Centro, São José dos CamposSão Paulo, SP 12245-760 (Brazil)E-Mail [email protected] have swelling after tattoo removal.com.br Received: March 07, 2019Accepted: May 01, 2019Published online: May 23, 2019Issue release date: May -August Number of Print Pages: 5Number of Figures: 2Number of Tables: 0 eISSN: 1662-6567 (Online) For additional information: https://www.karger.com/CDE This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC).
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions.
Making mistakes is part of growing up as a young adult. For some people, getting a tattoo is the mistake that lives with them every day. Luckily, with modern advances in technology, there are various ways to partially and fully remove unwanted ink. Depending on the technology used and the expertise of the tattoo remover, most people come out of tattoo removal procedures satisfied.
Some people may experience scarring, changes in skin texture, and burns after getting their tattoos removed. While these effects vary case by case, people with sensitive skin who are predisposed to excessive scarring may want to take precautions. Continue reading to learn more about tattoo removal and what you can do to mitigate the side effects associated with it.
The specialized laser shoots bursts of light energy that become absorbed by the ink particles in the dermis of the skin. Different levels of light energy are used to target different pigments of ink and help extract them from the body. The laser technology used in this process is called “Q-switching,” also known as “giant pulse formation.” This technique was developed and implemented in the 1960s and has since been used for a variety of purposes including metal work, precision measurement and, of course, tattoo removal.
Tattoo removers do not need to carry a medical license to practice, so it’s important to find a reliable professional who knows what he/she is doing. Depending on several factors, a patient may need anywhere from three to ten treatments (and sometimes more) for complete removal. Tattoo size, amount of colors present, and cover-up of a previous tattoo all factor into the number of required treatments for complete removal.
On average, six to eight weeks of wait time is required between sessions to attain optimal results. Tattoo removal procedures are accompanied by at least some pain which patients say is comparable to getting a tattoo. After a tattoo removal treatment, patients may experience bruising, swelling, redness, blisters, tenderness, and hyperpigmentation.
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In rare cases, having your tattoo removed can lead to scarring. If a scar was present at the site before receiving the tattoo, it will still be there after tattoo removal. If scarring was induced upon receiving a tattoo, laser treatments for tattoo removal will expose the previously-attained scar.
Not all states require certification to fire a laser – should you tip tattoo removal. Some clinics only have the basic laser operations training (one day) that comes with the purchase of a new laser. Some won’t even have that if they purchased their equipment used (yikes). It’s always wise to look into these things, and ask questions.
they will be equipped with the following expert grade certifications: These two certifications are considered the gold standard in this industry. Following your aftercare instructions is extremely important for preventing laser tattoo removal scars. The details should be explained to you precisely by your technician. Complications are very rare, but if they do occur, 99% of the time it’s due to patient non-compliance with aftercare instructions.
The healing process can make or break the overall outcome of your skin’s appearance. Blistering is normal and can occur after any laser session. Blisters mean that your immune system is trying to heal by removing the ink from your skin. They can appear after any treatment. However, you’re most likely to get them after your first couple treatments, due to the higher amount of ink density.
If they do pop, let the skin flake off on it’s own, don’t pick the skin away. will laser tattoo removal leave a scar. Picking at the skin or popping the blisters can result in scarring or infection. Blisters are a normal part of the healing process, and taking care of them is an extremely important step in tattoo removal scar prevention.
You need to keep your ink covered throughout your entire treatment plan to avoid burning or related scarring. Obviously you can’t avoid being outside. But if you plan on being outside during your treatment plan, keep an SPF 25 sunblock over the treated area. This instruction should also be followed two months following your last appointment, just to be safe.
Check this helpful resource on this subject: While it’s not always necessary to keep it covered, your treatment site needs to be kept clean. Any kind of dirt or grime will interfere with the healing process and could induce skin related side effects. It’s recommended to gently clean the area with soap and water at least a couple times a day with sensitive skin soap or body wash.
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Many of us pick away at scabs without thinking twice about it. More of a bad habit than anything else. Scabbing may develop during the later stages of a treatment plan, when high laser energy is needed. During which time, it’s vital that you let the scabs flake off on their own.
Simple daily rituals like cleaning the tattoo site a couple times daily will avoid infection. Do not allow the skin to become scraped in any way, it could result in infection and/or scarring. Shaving the treatment area should also be avoided, until it’s fully healed. Using triple antibiotic ointment like Neosporin while it’s healing is recommended.